Aim of review.To analyze the update to in the Rome-IV criteria for the functional heartburn and reflux hypersensitivity syndrome in comparison to the Rome-III criteria.Summary.The definition of functional heartburn in the Rome-IV criteria is updated by the statement according to which absence of response to the proton pump inhibitor therapy is indi
Plexins are cell surface receptors that bind semaphorins and transduce clothing signals for regulating neuronal axon guidance and other processes.Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates the Ras homolog Rap through an ill-defined non-canonical catalytic mechanism.The plexin
Abstract Background The growth factor receptor bound protein 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14.Each can interact with the insulin receptor and other receptor tyrosine kinases, where Grb10 and Grb14 inhibit insulin receptor activity.In cell culture studies they mediate functions including cell survival, p
We report for the first time the genomics of a nuclear compartment of the eukaryotic cell.454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different gene families and certain satellite repeats as the major building blocks of NADs, which constitute
Water is a limiting factor in Florida citrus production during the majority of the year because of the low water holding capacity of sandy soils resulting from low Concrete Plate clay and the non-uniform distribution of the rainfall.In Florida, the major portion of rainfall comes in June through September.However, rainfall is scarce during the dry